序贯免疫
sequential immunization
之前打了两针vero灭活，当时还在纠结于打不同一品牌会出事，
今天提醒说打第三针时间到了，拿到那张纸没有看，打完了针留观期间无聊才看看，发现是安徽智飞cho细胞，换了很多关键词才发现，cho细胞可以在打完两针vero灭活后作为第三针加强针注射。
文盲了，真的第一次听说，然后这个 sequential immunization 只有the little dict里有收录，TLD
Song S, Zhou B, Cheng L, Liu W, Fan Q, Ge X, Peng H, Fu YX, Ju B, Zhang Z. Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice. Virol J. 2022 Jan 4;19(1):2. doi: 10.1186/s12985-021-01737-3. PMID: 34983583; PMCID: PMC8724645.
link
Fully vaccinated people in China can now choose to receive a different shot from their original inoculation as a booster in a process called sequential immunization.
Here are some important details you should know about the sequential booster immunization.
1. What is sequential immunization?
Sequential immunization is a vaccination strategy that uses different types of vaccines for original and booster inoculations.
2. Who can get a sequential COVID-19 booster shot?
People must meet the following requirements to be eligible:
- Over 18 years old;
- Fully vaccinated with inactivated vaccines produced by Sinovac, Sinopharm Beijing or Sinopharm Wuhan;
- At least 6 months have passed since a second dose has been inoculated.
3. What are the vaccine options for a sequential booster shot?
Those eligible can choose between a protein subunit COVID-19 vaccine made by Anhui Zhifei Lingcom Biopharmaceuticals and a viral vector vaccine developed by CanSino Biologics.
4. What are the advantages of sequential immunization?
Sequential immunization is often rolled out when dealing with tricky and fast-mutating viruses.
This method is favored for combining the advantages of different vaccines and preventing people at risk of side effects for one particular kind of vaccine from going through them again.
Compared with a homologous booster vaccination strategy, sequential immunization can improve the breadth, strength, durability and functionality of immune response.
5. Has the sequential immunization strategy been adopted in other countries?
A number of countries in the Americas, Europe and Southeast Asia have already begun using different vaccines from those originally given for their booster shot programs.
The World Health Organization said it supports a flexible approach to boosting with a same or different dose.
6. What is the safety and efficacy of the sequential immunization strategy?
The approach has proved to be safe and effective based on domestic and foreign studies.
No additional side effects were found to be linked to a sequential booster.
7. Do I need to have both homologous and sequential booster vaccinations?
Research has shown either boosting with a dose that is the same as the initial inoculation or with a dose developed with a different technology is effective at further improving immunity against COVID-19. The eligible group only needs to choose one of them.
：这是学习笔记，不是讨伐文案，所以不要上纲上线。
